phenobarbital sodium molecular weight - An Overview
phenobarbital sodium molecular weight - An Overview
Blog Article
Keep an eye on Intently (1)pentobarbital will lower the extent or effect of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to the lower in fentanyl plasma concentrations, deficiency of efficacy or, potentially, development of a withdrawal syndrome inside of a affected person who's got designed physical dependence to fentanyl. After stopping a CYP3A4 inducer, given that the effects of the inducer decline, the fentanyl plasma concentration will maximize which could increase or prolong both equally the therapeutic and adverse effects.
pentobarbital will lessen the level or effect of mavacamten by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will lessen the level or effect of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Contraindicated (1)pentobarbital will decrease the level or effect of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with solid CYP3A4 inducers will not be suggested
Phenytoin, sodium valproate, valproic acid: The effect of barbiturates around the metabolism of phenytoin appears for being variable. Some investigators report an accelerating effect, while others report no effect. As the effect of barbiturates on the metabolism of phenytoin isn't predictable, phenytoin and barbiturate blood stages get more info really should be monitored extra routinely if these drugs are provided concurrently.
pentobarbital will decrease the extent or effect of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not proposed; strong cytochrome P450 enzyme inducers lessen systemic exposure to roflumilast and should reduce the therapeutic effectiveness
pentobarbital will minimize the level or effect of voriconazole by affecting hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Not known.
fentanyl transdermal and pentobarbital the two increase sedation. Stay clear of or Use Alternate Drug. Limit use to people for whom alternative remedy options are inadequate
pentobarbital will reduce the level or effect of zaleplon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.
pentobarbital will reduce the level or effect of loratadine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Monitor Intently (1)pentobarbital will minimize the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Contraindicated (one)pentobarbital will minimize the extent or effect of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the extent or effect of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic effect of elbasvir/grazoprevir can be lowered if coadministered with potent CYP3A inducers and is for that reason contraindicated.
pentobarbital decreases levels of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Keep away from Except the coadministration outweighs the attainable chance of ponatinib underexposure; check for indications of diminished efficacy.